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Germany’s start-up boom hits record high as AI and innovation drive 29% growth

From Berlin’s bustling hubs to quiet labs in Rostock, a wave of ambition is redefining Germany’s economy. Could RNA research be the next big leap?

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Few new start-ups in MV - Record high nationwide - Germany’s start-up boom hits record high as AI and innovation drive 29% growth

Germany’s start-up scene has surged in 2025, with a record 3,568 new companies launched—a 29% jump from the previous year. The boom is driven by enthusiasm for artificial intelligence and a wave of innovative business ideas. Meanwhile, in Mecklenburg-Western Pomerania, a small but promising research breakthrough is gaining attention in the field of kidney disease treatment.

The national rise in start-ups has been sharp, with Berlin leading at 16.8 new ventures per 100,000 residents—far above the national average of 4.3. Investors have backed this growth, injecting nearly two billion euros into new businesses in the final quarter of 2025 alone. Some analysts suggest the economic downturn may also be pushing more people toward entrepreneurship.

In stark contrast, Mecklenburg-Western Pomerania recorded just 17 new start-ups, the lowest in the country. Despite this, the region is making strides in research. At Universitätsmedizin Rostock, Prof. Sebastian Scharpf’s team is developing RNA-based therapies for kidney diseases. Their latest discovery, now under patent review, aims to bridge the gap between lab research and real-world medical use. The state’s Economy Minister, Wolfgang Blank, is actively promoting start-up culture to boost local innovation. Meanwhile, the Greifswald researchers are seeking stronger transatlantic partnerships to speed up clinical applications for their work.

The record number of start-ups reflects Germany’s growing interest in AI and new business models. In Mecklenburg-Western Pomerania, while start-up numbers remain low, advances in medical research offer potential for future growth. The patenting of RNA-based kidney therapies marks a step toward turning scientific progress into practical treatments.

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