4DMT Nears Breakthroughs in Gene Therapy for Macular Degeneration by 2026
The field of genetic medicine is advancing rapidly, with increasing focus on therapies that ease patient treatment while ensuring safety and long-term benefits. 4D Molecular Therapeutics (4DMT) is now approaching several key milestones in its gene therapy research, particularly in retinal disorders like wet age-related macular degeneration (AMD) and diabetic macular edema.
By early January 2026, 4DMT had enrolled 381 patients globally in its Phase 2 studies for wet AMD, specifically in the 4FRONT-1 trial. The company's lead candidate for this condition is in late-stage development, with North American trials fully enrolled and plans to expand into worldwide markets.
The year 2026 will see multiple important updates from 4DMT. Financial results are set for release in late February. In mid-2026, the company will present two-year data from the Phase 2b PRISM study, offering insights into the long-term performance of its vector platform. The third quarter will mark the launch of a global Phase 3 trial for diabetic macular edema.
Additionally, the second half of the year will include the completion of patient enrollment for the global Phase 3 4FRONT-2 study. New data from the SPECTRA Phase 1/2 trial will also be shared, further evaluating the therapy's effectiveness over time.
These developments highlight 4DMT's progress in gene therapy for retinal diseases. The upcoming data releases and trial expansions will provide clearer evidence of the treatment's durability and safety. The company's focus remains on reducing patient burden while delivering long-term clinical results.
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